The Pulmonary Metastasectomy in Colorectal Cancer cohort study: Analysis of case selection, risk factors and survival in a prospective observational study of 512 patients

Aim We wanted to examine survival in patients with resected colorectal cancer (CRC) whose lung metastases are or not resected. Methods Teams participating the study of Pulmonary Metastasectomy Colorectal Cancer (PulMiCC) identified potential candidates for metastasectomy and invited their consent join Stage 1. Baseline data related CRC fitness surgery were collected. Eligible randomization PulMiCC randomized controlled trial (Stage 2). Sites provided case report forms non-randomized record adverse events death at any time. They all reviewed 1 year. analysed full cohort. Results Twenty-five clinical sites recruited 512 from October 2010 January 2017. Data collection closed 2020. Before analysis, 28 non-CRC lesions excluded three had withdrawn leaving 481. The date was known 292 patients, 136 alive 2020 53 earlier time points. factors 5-year strata: 128 did have metastasectomy; 263 elective 90 trial. proportions solitary electively operated non-operated 69% 35%. Their respective survivals 47% 22%. Conclusion Survival without greater than widely presumed. Difference appeared be largely selection. No inference can drawn about effect on this observational study.